|6-(4-(4-甲基噻唑-2-基)-1H-咪唑-5-基)苯并噻唑盐酸盐|CsnPharm

CAS No.: 2459963-17-6

TP0427736 HCl is the HCl form of TP0427736 which is an inhibitor of ALK5 with IC50 of 2.72 nM and can reduce TGF-β induced growth.

规格	价格	促销价格	库存	数量

400-920-2911

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400-920-2911

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描述The transforming growth factor-β (TGF-β) type I receptor kinase ALK5 (activin receptor-like kinase 5) is an attractive target for intervention in TGFβ signaling due to its druggability as well as its centrality and specificity in the pathway^[1]. TP0427736 potently inhibited ALK5 activity, with an IC₅₀ value of 2.72 nM. Its ability to inhibit ALK3 was quite low compared with ALK5, with an IC₅₀ value of 836 nM.^[2]. TP0427736 inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 in a concentration-dependent manner, with an IC₅₀ value of 8.68 nM. TP0427736 rescues proliferation of outer root sheath cells suppressed by TGF-β^[2]. The topical application of TP0427736 significantly decreased Smad2 phosphorylation in mouse skin, and its repeated application suppressed the shortening of average hair follicle length during the transition from the late anagen phase to the catagen phase^[2]
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实验方案

技术信息

CAS号

2459963-17-6

储存条件

分子式

C14H11ClN4S2

运输

蓝冰

分子量

334.85

别名

溶解度

DMSO	75.0 mg/mL (224.0 mM) warming
Water	insoluble

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